Sulfadiazine sodium shine maganin rigakafi na sulfonamide matsakaici mai aiki wanda ke da tasirin kashe kwayoyin cuta akan yawancin ƙwayoyin gram-positive da gram-korau. Yana da tasirin antibacterial akan Staphylococcus aureus wanda ba ya haifar da enzyme, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, da Haemophilus mura. Har ila yau, yana aiki akan Chlamydia trachomatis, Nocardia asteroides, Plasmodium, da Toxoplasma in vitro. Ayyukan antibacterial na wannan samfurin daidai yake da na sulfamethoxazole. Koyaya, a cikin 'yan shekarun nan, juriya na ƙwayoyin cuta ga wannan samfur ya ƙaru, musamman Streptococcus, Neisseria, da Enterobacteriaceae.