2-methyl-5-nitroimidazole
Bayanan asali:
Sunan sinadaran: 2-methyl-5-nitroimidazole;
Sunan Ingilishi: 2-Methyl-5-nitroimidazole;
Lambar CAS: 88054-22-2
Tsarin kwayoyin halitta: C4H5N3O2
Nauyin Kwayoyin: 127.1
Lambar EINECS: 618-108-7
Tsarin tsari:
Rukunin masu alaƙa: albarkatun ƙasa; Matsakaicin magunguna; Kayan albarkatun magunguna.
Girma: 1.4± 0.1g/cm3
Tushen tafasa: 399.5± 15.0 °C a 760 mmHg
Matsayin narkewa: 252-254ºC
Matsakaicin walƙiya: 195.4± 20.4 °C
Matsakaicin adadin: 127.038177
PSA: 74.50000 LogP: -0.10
Bayyanar: Farin crystal
Matsin tururi:0.0±0.9mmHg a 25°C
Fihirisar magana: 1.592
Yanayin ajiya: an rufe shi a cikin sanyi da bushewa na 0-6ºC
Kwanciyar hankali: ba zai rube lokacin amfani da kuma adana shi bisa ga ƙa'idodi.
| ƙayyadaddun bayanai | naúrar | misali |
| Bayyanar | Kamar fari ko rawaya foda | |
| Abun ciki | % | ≥99% |
| Danshi | % | ≤0.3 |
| Sulfate | % | ≤0.3 |
Yafi amfani a cikin kira na metronidazole, dimetazole da sauran kwayoyi intermediates.
Ana samun shi ta hanyar nitration na 2-methylimidazole. Saka sulfuric acid, 2-methylimidazole da sodium sulfate a cikin tukunyar amsawa, motsawa da zafi, ƙara nitric acid a 150-160 ℃, ƙara sama, bi yanayin akwati na 1 hour. Cire zafin jiki zuwa 140 ℃ a ƙasa, bayan ƙara ruwa tare da ruwan ammonia don daidaita pH zuwa 3.5-4, crystallization. Iri, wanke zuwa tsaka tsaki, bushe, 2-methyl-5-nitroimidazole.
25k kraft takarda jakar ko jakar da aka saƙa (58 × 110) da aka yi da jakar filastik, 250kg fitarwa jakar jaka (100 × 80); Dangane da bukatun abokin ciniki;
Rufe ajiya, adana a cikin sanyi, duhu, busasshen sito, ajiya da sufuri ya kamata ya zama haske, don hana lalacewa da danshi, an haramta shi sosai tare da kwayoyi masu gauraye.
Hanyar samarwa: An samu ta hanyar nitration na 2-methylimidazole. Saka sulfuric acid, 2-methylimidazole da sodium sulfate a cikin tukunyar amsawa, motsawa da zafi, ƙara nitric acid a 150-160 ℃, ƙara sama, bi yanayin akwati na 1 hour. Cire zafin jiki zuwa 140 ℃ a ƙasa, bayan ƙara ruwa tare da ruwan ammonia don daidaita pH zuwa 3.5-4, crystallization. Iri, wanke zuwa tsaka tsaki, bushe, 2-methyl-5-nitroimidazole.
